Objective Many studies have shown that patients with coronary artery disease have an exaggerated rise and a delayed fail of plasma triglyceride (TG) concentration postprandialiy but the plasma TG response to a fatty meal in patients with essential hypertension. Material-Method A fatty meal (83.5% fat, 1604 kcal per 2 m2 body surface) was given to 25 patients with essential hypertension (H), and 25 normotensives (N). The two groups were matched for age, body mass index, lipid profile, basal glucose and insulin concentrations, and an index of homeostasis model of insulin resistance (HOMA-IR). Blood samples were taken 0, 4, 6, and 8 hours after the fatty meal. Lipid variables were measured in all samples. Blood glucose and insulin levels were measured in the fasting state. Results Total and high density lipoprotein cholesterol, apolipoprotein A and B and HOMA-IR did not differ significantly over time between the groups. The plasma TG concentration (mg/dL) increased significantly after fat loading in H (from 118±31 to 284±137 at 4 hours, 327±93 at 6 hours and 285±71 at 8 hours) compared to N group (from 105±29 to I50±38 at 4 hours, 146±42 at 6 hours and 115±38 at 8 hours), P=0.001, <0.001, and <0.001, respectively. Conclusions This study suggests that patients with hypertension have an exaggerated response and delayed clearance of plasma TG concentration after fat loading.