Introduction: The global outbreak of the SARS-CoV-2 virus and the subsequent COVID-19 pandemic have led to various health challenges worldwide. Among the emerging concerns is the condition known as Long COVID-19, which presents persistent symptoms and effects even after the initial recovery from the acute phase of the illness. Aim: This paper presents an in-depth case study of the X family, a Greek family facing the challenges of Long COVID-19, a syndrome sequel to SARS-CoV-2 infection. The study explores the physical, psychological, and social effects of Long COVID-19 on the family as well as its self-management. Method: The case study method employed in this research involves an intensive investigation of a single-family unit, providing a detailed understanding of their experiences and challenges related to Long COVID-19. This qualitative approach allows for a holistic exploration of the subject, capturing the intricate nuances of the family's journey through Long COVID-19. Results: The findings highlight the significant burden on the family due to the occurrence of the syndrome in one of its members, as well as the resolution of problems through cooperation, effective communication, and the strong emotional bonds of its members. Conclusions: In conclusion, it emphasizes the need to design a comprehensive, multifaceted plan of care tailored to the unique needs and strengths of the family and outlines potential challenges in its implementation, with a view to its wider use in the community.