Epilepsy is a neurological disorder that leads to occasional epileptic seizures, affecting the quality of life. Aim: The aim of the present study was to explore the current psychological and social profile of epileptic patients in Greece and to identify the main differences as compared to a former similar research. Material and Methods: A sample of 91 questionnaires, from a total of 350 inpatients with epilepsy at a Public Hospital, during the years 2008 to 2009 (response rate 26%). For data analysis, we used simple descriptive statistical analysis (at significance level of α=5% and α=10%) and factor analysis, using SPSS 16.0. Results: Our research showed that the quality of life of people with epilepsy in Greece seems to have improved significantly during the last decade, as their crises have been reduced by 15,7% and their employment has increased by 13% . Conclusions: All that mean that these people are no longer been placed in the margin of society and they succeed in living a normal life with the certain limitations of their disease.