Metabolic Syndrome (MS) is consisted by a group of interrelated disorders increasing the risk for cardiovascular diseases and type II diabetes causing diseases and deaths in modern world. Purpose of the current study is to relate the evaluation of the metabolic syndrome parameters in clinical practice. Data sources and methods: The methodology which was used in this study included Greek and international bibliography review with the help of key-words. Results: Bibliography review showed that the criteria for Metabolic Syndrome are not well-defined and vary according to age, gender and race, while new risk factors are identified every day. Unhealthy diet and lack of physical activity are the basic features of obesity in childhood and adolescence. As a result, the frequency of metabolic disorders constantly increases in overweight or obese children and adolescents and therefore it is necessary for the diagnosis of the syndrome. Conclusions: Metabolic Syndrome management should be based upon an individualized risk assessment and not upon a simple summation and effort in getting treatment separately for each metabolic disorder. Prompt diagnosis and treatment of children and adolescents with multiple risk factors will contribute substantially to prevention by adopting a healthy lifestyle and reducing future syndrome complications.