Cancer and particularly lung cancer, which is the most prevalent form of cancer worldwide, constitute a major health problem in developed countries. Beyond physical problems, the prevalence of psychiatric morbidity is also high. Aim: Τo investigate the prevalence of two major psychological disorders, anxiety and depression in patients with lung cancer. Materials and Methods: One hundred and twenty eight (128) patients of a provincial general hospital filled in the Hospital Anxiety and Depression Scale (HADS). Descriptive and analytic statistics was performed. SPSS 17.0 was used for analysis. Statistical significance was set at p<0.05. Results: Males were 55.5 % of the sample. Less than 10 % had severe complications. The estimation of depression in the sample was 18%, while anxiety was estimated at 10% of the sample. Statistically significant differences were observed between depression and gender (p=0.035) and anxiety and alimentary system complications (p=0.002). Conclusion: Patients suffering from lung cancer exhibit high levels of anxiety and depression. Gender and alimentary tract complications seem to associate with psychological disorders.