The Rheumatoid Arthritis (R.A.) is one from the more usual rheumatic diseases of adult life and causes dysfunctions with enormous cost in the natural situation, as well as in professional, familial, social and psychological sector. The disease is characterized from chronically, multiplicity and fluctuation of intensity of symptoms, inability quantified the future prognosis of the disease, symptomatic and no causative therapy. The R.A. is characterized as chronic disease, owed in the interaction of various pathological factors: genetics, bodilies, and psychological. The acceptance of chronic disease from the patient with R.A. is not a conveniently process. The patients with chronic illness find itself in a continuous pressure and the psychological, social and financial problems, which are created at its confrontation, need medical-nursing intervention. The creation of good communication with the patient with R.A. will be decisive for his therapeutic approach and the holistic relief of illness. Aim of this review is are investigated all the causative factors that contribute in the event of R.A., as well as are sought the most contemporary and evolved therapeutic methods of confrontation.