Grounded theory consists a distinctive research approach which aims to discover theories grounded in social processes. It is based on symbolic interactionism and has been utilized in many disciplines such as psychology, education, philosophy and musing. This paper discusses the main features of the grounded theory methodology by analyzing the overall sampling design, data collection methods, the use of constant comparative analysis and issues relating to the review of literature in conducting grounded theory research. Additionally the notion of 'self in qualitative interviews is debated. The use of the approach is proposed of having immense value in revealing unknown theories grounded in Greek nursing practice and education.